Continuous Skin Rejuvenation by Combining Nonablative Fractional Laser With Daily Application of a Multibeneficial Composition Formulation: A Blinded Randomized Clinical Trial Study

The supplied index reports a single-centre, double-blind, randomised split-face trial: 37 enrolled, 33 women aged 35–49 completed; after one full-face nonablative fractional laser treatment, a multi-ingredient serum and a blank formulation were applied to opposite sides twice daily for 28 days. Instrumental and physician assessments recorded changes in several wrinkle and nasolabial fold parameters; no serious adverse events occurred, and one mild oedema attributed to laser resolved within three days.