Apigenin promotes melanogenesis and melanosome transport through the c-KIT/Raf-1/MAPK/CREB pathway in HEMCs

The supplied index reports that apigenin was examined in human epidermal melanocytes, zebrafish embryos, and human skin explants, using melanin measurement, microscopic observation, and inhibition/knockdown of the c-KIT pathway. At 10 µM, melanin production in melanocytes reached 1.8 times the control level; increased pigmentation and reduced UVB-related DNA damage markers were observed in skin explants.