PEER-REVIEWED ARTICLE
Application of an in vitro reconstructed human skin coculture with THP-1 on cosmetics in skin sensitization
Bo Wang · Hongyu Ma · Yuying Cheng · Dangdang Cheng · Feifei WangToxicology letters 2025, 413(), 111738DOI 10.1016/j.toxlet.2025.111738 ↗
The supplied index reports: A reconstructed-skin/THP-1 coculture was used to detect CD54, CD86, and IL-18, and compared with human patch testing to evaluate the sensitization potential of cosmetic formulations. Under the thresholds used in the paper, the method showed an overall sensitivity of 56.52% and 75% for cleansing products.
Overall sensitivity 56.52%.Detection sensitivity of the method for all tested products under the paper's sample and thresholds.
Sensitivity of 75% for cleansing products, with variation across product types.The higher sensitivity in the cleansing subgroup does not apply to all cosmetic categories.
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Complete publication and citation identifiers.
- DOI
- 10.1016/j.toxlet.2025.111738
- ISSN
- Published
- 2025-09-30
- Volume / Issue / Article
- 413 / / 111738
- Publisher
- Keywords