K-Nearest Neighbour-based classification of skin barrier damage using Raman imaging: A non-invasive assessment method for skin damage severity

The supplied index reports: Tape stripping and friction were used to establish controlled barrier-damage models; Raman imaging measured stratum corneum thickness, lipid content and keratin signals, which were input into a K-nearest neighbour classifier. The method distinguished normal to more severe damage and classified unknown samples under the tested conditions.