Paeonia suffruticosa Andrews root extract ameliorates photoaging via regulating IRS1/PI3K/FOXO pathway

The supplied index describes a study on Paeonia suffruticosa root-bark extract (PSAE). The work combined compositional and in vitro antioxidant assays, UV-exposed keratinocytes and fibroblasts, a 3D skin model, and single-application human forearm evaluation at 2, 4 and 6 hours. Under the tested conditions, the extract modulated ROS, senescence markers and collagen-related indicators, influenced the IRS1/PI3K/FOXO pathway, and short-term instrumental changes in TEWL, hydration, roughness and elasticity parameters were observed relative to baseline.