PEER-REVIEWED ARTICLE

A study on the anti-senescent effects of flavones derived from Prinsepia utilis Royle seed residue

Junxi Liu · Liping Qu · Feifei Wang · Zaoju Mei · Xinlang Wu · Bo Wang · Haiyang Liu · Li HeJournal of ethnopharmacology 2024, 328(), 118021DOI 10.1016/j.jep.2024.118021 ↗

The supplied index reports on a study in which a flavonoid fraction (PURF) was isolated from Prinsepia utilis seed residue and assessed through biochemical assays, zebrafish, a D-galactose-induced mouse ageing model, and human fibroblast and 3D full-thickness skin models. Under the tested conditions, PURF inhibited free radicals, collagenase, and elastase in biochemical assays and modulated senescence-related markers and AMPK/mTOR/TGF-β pathway protein expression in the animal and cell-based models.

The tested flavonoid fraction PURF showed inhibitory activities against free radicals, collagenase, and elastase in biochemical assays.Findings recorded in the supplied index

In the D-galactose-induced mouse ageing model, zebrafish, and in human fibroblasts and 3D full-thickness skin models, PURF treatment modulated senescence-related markers and the expression of proteins in the AMPK/mTOR/TGF-β pathway.Findings recorded in the supplied index

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