Prinsepia utilis Royle polysaccharides promote skin barrier repair through the Claudin family

The supplied index reports that a water-extracted preparation (PURP) containing polysaccharides and proteins was obtained from Prinsepia utilis fruit meal, and tested using SDS-damaged reconstructed human epidermis, mouse skin barrier injury, and IL-4-stimulated cell models. Under the tested conditions, PURP treatment increased transepithelial electrical resistance, reduced permeability, and upregulated Claudin-family expression in reconstructed epidermis, and decreased transepidermal water loss in mice.