PEER-REVIEWED ARTICLE
Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathway
Shuhong Zhang · Yueyue Chen · Liping QuScientific Reports 2025, 15(1), 8260DOI 10.1038/s41598-025-92559-8 ↗
The supplied index reports: This in vitro study examined the effects of Rosa roxburghii extract on UVB‑irradiated keratinocytes, measuring inflammatory mediators and IL‑17 pathway markers, and also used an inflammation‑conditioned fibroblast model to assess senescence‑associated β‑galactosidase, COL1A1, and secretory phenotype. The extract reduced multiple inflammatory mediators and pathway indicators, and fibroblast senescence markers showed corresponding alterations.
Treatment with Rosa roxburghii extract reduced several inflammatory mediators and IL‑17 pathway indicators in keratinocytes.UVB‑stimulated keratinocyte model with extract treatment
Keratinocyte‑derived inflammatory signals influenced fibroblast senescence‑associated markers, including β‑galactosidase, COL1A1 and secretory phenotype changes.Inflammatory factor‑mediated fibroblast senescence model
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- DOI
- 10.1038/s41598-025-92559-8
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- Published
- 2025-03-10
- Volume / Issue / Article
- 15 / 1 / 8260
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