基于网络药理学的复配活性物多层次抗老机制研究

输入索引记载：该研究对一种包含八种成分的复配体系进行了网络药理学分析，并辅以体外表皮、真皮和组织层面实验。网络药理学识别出24条与皮肤衰老显著相关的通路；体外实验观察到成纤维细胞增殖、屏障基因表达上调及胶原、氧化应激相关指标的变化，同时金钮扣花提取物在斑马鱼胚胎中表现出神经放松活性。

The supplied index reports: This study investigated an eight-ingredient bioactive composition using network pharmacology and subsequent in vitro experiments at epidermal, dermal, and tissue levels. Network pharmacology identified 24 statistically significant pathways associated with skin aging; in vitro experiments showed fibroblast proliferation, upregulation of barrier-related genes, and changes in collagen and oxidative stress markers, while the Acmella oleracea extract constituent demonstrated neuro-relaxing activity in zebrafish embryos.