PEER-REVIEWED ARTICLE · 同行评议论文
芹菜素促进黑色素生成与运输的c-KIT通路研究
Apigenin promotes melanogenesis and melanosome transport through the c-KIT/Raf-1/MAPK/CREB pathway in HEMCs输入索引记载，研究使用人表皮黑色素细胞、斑马鱼胚胎和人离体皮肤，通过色素测量、显微观察及c-KIT通路抑制与基因敲低等方法，观察芹菜素对黑色素生成、树突形成和黑素小体成熟的影响。在10 μM浓度下，黑色素细胞黑色素生成达到对照的1.8倍；离体皮肤中观察到色素增加及UVB相关DNA损伤指标下降。
护肤研发启示
索引整理者指出，该研究有助于区分不同植物黄酮对色素的作用方向，避免将植物活性笼统归为美白。
The supplied index reports that apigenin was examined in human epidermal melanocytes, zebrafish embryos, and human skin explants, using melanin measurement, microscopic observation, and inhibition/knockdown of the c-KIT pathway. At 10 µM, melanin production in melanocytes reached 1.8 times the control level; increased pigmentation and reduced UVB-related DNA damage markers were observed in skin explants.
Relevance to skincare research
The index compiler notes that the study helps distinguish the pigmentation direction of different plant flavonoids, cautioning against broadly classifying all plant activities as skin‑lightening.
STUDY INFORMATION
研究信息
实验范围与结果
- 所提供的资料为BTN研究索引，并非原始全文。
- 离体人皮肤实验中DNA损伤指标下降不能替代已建立的防晒指数（SPF）测定。
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论文身份与引用信息。
- 原文题名
- Apigenin promotes melanogenesis and melanosome transport through the c-KIT/Raf-1/MAPK/CREB pathway in HEMCs
- 作者
- Jinpeng Lv · Duo Meng · Huansha Zhang · Wenhui Xu · Xiaohong An · Chuanwei Yin · Kun Zou · Rongyin Gao
- DOI
- 10.3389/fphar.2025.1572878
- ISSN
- 发表日期
- 2025-04-28
- 期刊
- Frontiers in pharmacology
- 卷 / 期 / 文章号
- 16 / / 1572878
- 出版社
- 关键词