PEER-REVIEWED ARTICLE · 同行评议论文
重建人皮肤与THP-1共培养评价化妆品致敏潜力
Application of an in vitro reconstructed human skin coculture with THP-1 on cosmetics in skin sensitization输入索引记载：该研究使用重建人皮肤与THP-1细胞共培养模型，检测CD54、CD86及IL-18，并与人体斑贴测试比较，评价化妆品配方致敏潜力。在论文设定的阈值下，该方法对全部产品的检出敏感度为56.52%，对清洁类产品为75%。
护肤研发启示
据索引资料，该研究为体外模型与人体斑贴组合评价提供案例，同时提示该方法存在漏检，不支撑零致敏宣称或替代全部安全评估。
The supplied index reports: A reconstructed-skin/THP-1 coculture was used to detect CD54, CD86, and IL-18, and compared with human patch testing to evaluate the sensitization potential of cosmetic formulations. Under the thresholds used in the paper, the method showed an overall sensitivity of 56.52% and 75% for cleansing products.
Relevance to skincare research
According to the index, the study provides a case for combining in vitro and human patch testing, but the method's detection gaps do not support zero-allergy claims or complete replacement of safety assessment.
STUDY INFORMATION
研究信息
实验范围与结果
- 输入索引资料，未提供原始论文全文。其他细节及讨论未知。
- 该体外方法在所测试条件下对产品的整体检出敏感度为56.52%，即约半数产品可能漏检。
- 清洁类产品的75%敏感度不能推广到全部化妆品类型。
PUBLICATION & FULL TEXT
PDF 与出版来源
PUBLICATION METADATA · 出版信息
论文身份与引用信息。
- 原文题名
- Application of an in vitro reconstructed human skin coculture with THP-1 on cosmetics in skin sensitization
- 作者
- Bo Wang · Hongyu Ma · Yuying Cheng · Dangdang Cheng · Feifei Wang
- DOI
- 10.1016/j.toxlet.2025.111738
- ISSN
- 发表日期
- 2025-09-30
- 期刊
- Toxicology letters
- 卷 / 期 / 文章号
- 413 / / 111738
- 出版社
- 关键词