PEER-REVIEWED ARTICLE · 同行评议论文
栀子果提取物与STAT6相关屏障及炎症机制研究
Gardenia jasminoides fruit extract alleviates MC903-induced atopic dermatitis and reduces IL-4/IL-13-induced tight junction disruption and inflammation by regulating the phosphorylation of STAT6输入索引记载，本研究在IL-4/IL-13刺激的角质形成细胞、3D表皮模型和MC903诱导的小鼠模型中测试栀子果提取物。结果表明，炎症因子IL-24、IL-33和CCL26表达下降，紧密连接蛋白CLDN1、CLDN4和OVOL1表达增加，并进一步通过基因干预和抑制剂实验观察STAT6磷酸化与这些变化的关联。
护肤研发启示
输入索引记载，本研究为植物提取物、炎症信号与屏障连接之间的机制研究提供模型。
The supplied index reports that gardenia fruit extract was tested in IL-4/IL-13-stimulated keratinocytes, reconstructed epidermis, and an MC903-induced mouse dermatitis model. Results showed decreased expression of inflammatory mediators IL-24, IL-33, and CCL26, increased expression of tight junction proteins CLDN1, CLDN4, and OVOL1, and further gene-interference and inhibitor experiments examining the association of STAT6 phosphorylation with these changes.
Relevance to skincare research
The supplied index reports that this study provides a model for investigating the relationship between plant extracts, inflammatory signaling, and barrier junctions.
STUDY INFORMATION
研究信息
实验范围与结果
- 输入索引记载，本研究未报告护肤产品的人体疾病治疗效果。
- 小鼠模型通过MC903处理建立，不等同于人体自然发生的特应性皮炎。
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PUBLICATION METADATA · 出版信息
论文身份与引用信息。
- 原文题名
- Gardenia jasminoides fruit extract alleviates MC903-induced atopic dermatitis and reduces IL-4/IL-13-induced tight junction disruption and inflammation by regulating the phosphorylation of STAT6
- 作者
- Peng Xu · Yaoying Wan · Xiaoli Jin · Yonglei Yuan · Hongyu Ma · Yichun Wang · Feifei Wang · Liping Qu
- DOI
- 10.1016/j.jep.2025.121124
- ISSN
- 发表日期
- 2026-01-02
- 期刊
- Journal of ethnopharmacology
- 卷 / 期 / 文章号
- 360 / / 121124
- 出版社
- 关键词