牡丹根皮提取物的光老化相关机制与多模型评价

本索引记载了一项以牡丹根皮提取物PSAE为对象的研究，采用成分与体外抗氧化分析、紫外线处理的角质形成细胞与成纤维细胞、3D皮肤模型以及前臂单次涂抹后2、4、6小时的人体仪器评价。在该研究条件下，提取物显示出对ROS、衰老标志物及胶原相关指标的调节作用，并影响IRS1/PI3K/FOXO信号通路，同时人体测量观察到经皮水分流失、含水量及部分皮肤粗糙度和弹性指标相对基线的变化。

The supplied index describes a study on Paeonia suffruticosa root-bark extract (PSAE). The work combined compositional and in vitro antioxidant assays, UV-exposed keratinocytes and fibroblasts, a 3D skin model, and single-application human forearm evaluation at 2, 4 and 6 hours. Under the tested conditions, the extract modulated ROS, senescence markers and collagen-related indicators, influenced the IRS1/PI3K/FOXO pathway, and short-term instrumental changes in TEWL, hydration, roughness and elasticity parameters were observed relative to baseline.