PEER-REVIEWED ARTICLE · 同行评议论文
马齿苋提取物与光老化：miR-138-5p/Sirt1机制研究
The extract from Portulaca oleracea L. rehabilitates skin photoaging via adjusting miR-138-5p/Sirt1-mediated inflammation and oxidative stress输入索引记载：该研究在紫外线诱导的小鼠光老化模型及UVB照射的BJ与HaCaT细胞中测试马齿苋提取物，观察组织形态、胶原与透明质酸相关指标、氧化应激和炎症变化。细胞活性与相关损伤指标出现改善，实验通过miR-138-5p过表达、抑制及Sirt1干预分析作用机制。
护肤研发启示
输入索引记载：该研究为马齿苋相关原料在光损伤与细胞调控方向提供了机制信息。
The supplied index reports that purslane (Portulaca oleracea) extract was investigated in UV-induced mouse photoageing and UVB-exposed BJ and HaCaT cells, measuring tissue changes, collagen and hyaluronic acid-related indicators, oxidative stress and inflammation. Improvement was observed in cell viability and related damage indicators, and the mechanism was examined via miR-138-5p overexpression, inhibition and Sirt1 intervention.
Relevance to skincare research
The supplied index suggests that the study provides mechanistic information on purslane-related ingredients in the context of photodamage and cellular regulation.
STUDY INFORMATION
研究信息
实验范围与结果
- 输入索引记载：小鼠给药剂量单位为mg/kg，不能直接换算为化妆品添加浓度。
- 输入索引记载：研究结果来自动物与细胞模型，未包含人体抗皱等功效测试。
- 本资料为BTN整理的研究索引，并非原始论文全文。
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PUBLICATION METADATA · 出版信息
论文身份与引用信息。
- 原文题名
- The extract from Portulaca oleracea L. rehabilitates skin photoaging via adjusting miR-138-5p/Sirt1-mediated inflammation and oxidative stress
- 作者
- Liping Qu · Feifei Wang · Xiao Ma
- DOI
- 10.1016/j.heliyon.2023.e21955
- ISSN
- 发表日期
- 2023-11-07
- 期刊
- Heliyon
- 卷 / 期 / 文章号
- 9 / 11 / e21955
- 出版社
- 关键词