PEER-REVIEWED ARTICLE · 同行评议论文
青刺果种子残渣黄酮的抗细胞衰老研究
A study on the anti-senescent effects of flavones derived from Prinsepia utilis Royle seed residue出版记录另有勘误 ↗，阅读原文时请一并查阅。
所提供索引记载，研究从青刺果种子残渣中分离黄酮组分PURF，并采用生化实验、斑马鱼、D-半乳糖诱导的小鼠衰老模型以及人成纤维细胞和3D全层皮肤模型进行评价。在所测试条件下，PURF在生化实验中对自由基、胶原酶和弹性蛋白酶表现出抑制活性，并在动物和细胞模型中调节衰老相关标志物及AMPK/mTOR/TGF-β通路蛋白表达。
护肤研发启示
该索引记载为利用青刺果副产物的黄酮组分及多模型原料评价提供了研究案例。
The supplied index reports on a study in which a flavonoid fraction (PURF) was isolated from Prinsepia utilis seed residue and assessed through biochemical assays, zebrafish, a D-galactose-induced mouse ageing model, and human fibroblast and 3D full-thickness skin models. Under the tested conditions, PURF inhibited free radicals, collagenase, and elastase in biochemical assays and modulated senescence-related markers and AMPK/mTOR/TGF-β pathway protein expression in the animal and cell-based models.
Relevance to skincare research
The index record provides a case for the utilization of flavonoid components from Prinsepia by-products and multi-model ingredient evaluation.
STUDY INFORMATION
研究信息
实验范围与结果
- 输入索引说明，未报告人体护肤品使用效果。
- 输入索引说明，细胞和3D皮肤相关表达变化未被换算为人体皱纹改善幅度。
PUBLICATION & FULL TEXT
PDF 与出版来源
PUBLICATION METADATA · 出版信息
论文身份与引用信息。
- 原文题名
- A study on the anti-senescent effects of flavones derived from Prinsepia utilis Royle seed residue
- 作者
- Junxi Liu · Liping Qu · Feifei Wang · Zaoju Mei · Xinlang Wu · Bo Wang · Haiyang Liu · Li He
- DOI
- 10.1016/j.jep.2024.118021
- ISSN
- 发表日期
- 2024-03-15
- 期刊
- Journal of ethnopharmacology
- 卷 / 期 / 文章号
- 328 / / 118021
- 出版社
- 关键词