青刺果多糖通过 Claudin 蛋白家族促进皮肤屏障修护

输入索引记载，该研究从青刺果果粕中水提获得含多糖和蛋白的提取物PURP，利用SDS损伤重建人表皮、小鼠皮肤屏障损伤及IL-4刺激细胞模型进行观察。在所测试条件下，PURP处理提高了重建人表皮的跨上皮电阻并上调紧密连接蛋白表达，同时降低了小鼠皮肤的经皮水分流失。

The supplied index reports that a water-extracted preparation (PURP) containing polysaccharides and proteins was obtained from Prinsepia utilis fruit meal, and tested using SDS-damaged reconstructed human epidermis, mouse skin barrier injury, and IL-4-stimulated cell models. Under the tested conditions, PURP treatment increased transepithelial electrical resistance, reduced permeability, and upregulated Claudin-family expression in reconstructed epidermis, and decreased transepidermal water loss in mice.