PEER-REVIEWED ARTICLE · 同行评议论文
刺梨提取物通过抑制IL-17通路对UVB诱导的炎症性衰老的保护作用
Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathway输入索引记载：本项体外研究利用刺梨提取物干预UVB照射的角质形成细胞，测定炎症介质与IL-17通路相关标志物，并在炎症因子处理的成纤维细胞中检测衰老相关β-半乳糖苷酶、COL1A1及分泌表型。结果显示提取物可减少多种炎症介质与通路指标，且成纤维细胞出现相应衰老标志改变。
护肤研发启示
输入索引指出，该研究为植物原料的炎症与衰老联动研究提供了细胞间相互作用视角。
The supplied index reports: This in vitro study examined the effects of Rosa roxburghii extract on UVB‑irradiated keratinocytes, measuring inflammatory mediators and IL‑17 pathway markers, and also used an inflammation‑conditioned fibroblast model to assess senescence‑associated β‑galactosidase, COL1A1, and secretory phenotype. The extract reduced multiple inflammatory mediators and pathway indicators, and fibroblast senescence markers showed corresponding alterations.
Relevance to skincare research
The supplied index notes that this study offers a cell‑interaction perspective for investigating the link between inflammation and ageing with botanical ingredients.
STUDY INFORMATION
研究信息
实验范围与结果
- 本索引资料来源于研究摘要，未提供完整实验数据和方法细节。
- 研究结果来自细胞体系，不能直接外推至人体抗皱效果；IL-17及TGF-β相关指标为机制观察，不代表皮肤疾病治疗结论。
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PUBLICATION METADATA · 出版信息
论文身份与引用信息。
- 原文题名
- Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathway
- 作者
- Shuhong Zhang · Yueyue Chen · Liping Qu
- DOI
- 10.1038/s41598-025-92559-8
- ISSN
- 发表日期
- 2025-03-10
- 期刊
- Scientific Reports
- 卷 / 期 / 文章号
- 15 / 1 / 8260
- 出版社
- 关键词