AOXMED—Master of Skin Rejuvenation

AOXMED—Master of Skin Rejuvenation

A high-end professional skin care brand under Botanee Group

As a high-end professional skin care brand developed by Botanee Group, a top player in China's beauty industry with the highest market value, AOXMED is the result of over a decade of committed efforts. This brand, rooted in scientific research and prioritizing efficacy, is designed for professional beauty and skin rejuvenation. As a brand specializing in skin rejuvenation, AOXMED knows well the importance of staying current. We are dedicated to scientific exploration and evidence-based research to effectively slow the aging process and maintain or even prolong youthful skin.

AOXMED stands for Aesthetic, Optimal, Exclusive, Muscle, Epidermis, and Dermis. Similarly, the Chinese name of the brand, "瑷科缦", embodies profound meanings: "瑷" signifies the beauty of all jade, "科" represents science, research, and technology, and "缦" refers to skin as soft as silk, emblematic of scientific precision and fine quality. Together, these Chinese characters reflect a blend of basic research, evidence-based science, and cutting-edge technology for skin care.

MLYAAT-1002®—Revolutionary Multi-layer Anti-aging Patent

In 2010, a visionary team of elite scientists with extensive pharmaceutical experience embarked on a journey to create China's skin health ecosystem. They dedicated themselves to exploring advanced technologies for skin rejuvenation, striving to develop cosmeceutical and anti-aging solutions for the professional beauty sector.

After 12 years of dedicated research, the AOXMED Skin Rejuvenation Academy, supported by a world-class R&D team and advanced experimental conditions, has gained deep insights into skin aging mechanisms in Chinese people. Experts found anti-aging active substances in rare plateau species from Yunnan's Shangri-La based on modern scientific and technological achievements. They conducted over 100,000 activity screenings using dozens of in vitro and in vivo evaluation models and identified over 200 anti-aging substances through rigorous orthogonal experiments. This led to the creation of over 5,000 unique formulation combinations. After meticulous selection of superior ingredients and the development of an optimal blend, AOXMED's core ingredient—MLYAAT-1002® multi-dimensional anti-aging essence—was successfully formulated.

MLYAAT-1002® multi-dimensional anti-aging essence, the exclusive ingredient of AOXMED, serves as the foundation of almost all formulas of the brand. In the light of aging mechanism, this ingredient works at different levels of the skin, offering consistent endogenous anti-aging effects. This involves resisting aging damage, aiding in collagen production, diminishing age-related marks, and reinforcing skin barriers.

Guided by a firm belief in science and a beautiful vision for future, the Academy has always embraced bold breakthroughs and innovations. Over the years, it has engaged in extensive partnerships with professional institutes, as well as institutions of higher learning, focusing on the physiological aspects of skin aging in China. By scientifically validating the safety and efficacy of products, the Academy continues to progress, pushing the boundaries of scientific research.

Mission of AOXMED

AOXMED's mission is for professional beauty, focusing on skin rejuvenation. Embracing the unique 3R skincare philosophy—REPAIR, REJUVE and RETAIN, AOXMED merges cosmeceutical products with professional beauty programs. In this manner, the brand is committed to delivering effective and safe professional beauty solutions and perfect skincare experience, thus maintaining your skin's youthful vitality.

According to different targets and formula systems, AOXMED offers the Rejuvenation series, Lift & Repair series, and Extract series products. Among the products offered, the Rejuvenation series products are specifically designed for skin repair and anti-aging maintenance post beauty programs. They feature a higher concentration of MLYAAT-1002® multi-dimensional anti-aging essence along with other active ingredients. In addition, to cater to the skin characteristics and anti-aging needs of Chines people, AOXMED has developed an exclusive MARS MLYAAT-1002® Ultra-Active Rejuvenation System tailored for maintenance following beauty programs. This system integrates several professional cosmeceuticals along with specialized beauty programs to enhance efficacy and ensure ongoing care. This delivers multi-dimensional anti-aging effects at various skin layers, internally aiding in collagen production and effectively combating various signs of aging.

The MLYAAT-1002® freeze-dried essence is free of additives such as preservatives, surfactants, and excipients. In combination with the super penetration enhancing technology, the ingredient ensures that superactive substances are delivered to the skin promptly following treatments. By considering the epidermis, dermis, and aging factors, it stimulates collagen activation while repairing, guaranteeing customers a multi-dimensional anti-aging effect and a premium experience.

Our Design Philosophy

Circles and squares, along with vertical and horizontal lines, are not only a symbol of traditional culture, but also a subtle fusion of modern science and art. The Yingzao Fashi, an architectural work of the Northern Song Dynasty, quoted Zhoubi Suanjing, an ancient astronomy and mathematics classic, saying: "The law of mathematics originates from the circle and square." "The circle and square represent the forms of heaven and earth, the numbers of yin and yang." "All things in the universe function by laws; and the master craftsman constructs by standards."

The heaven is round and in motion, while the earth is square and stationary, creating a balance between static and dynamic states, incorporating both rigidity and softness.

Skin, woven like the warp and weft, unites as one, ever-changing but containing law and order.

As shown in the figure above, the Flower of Rejuvenation, with intersecting geometric lines, highlights the skin's natural texture and fosters youthful energy and boundless vitality within the hexagon, a symbol of science.

As shown below, the measuring scale reflects a rigorous attitude towards science, a precise grasp of efficacy, and the ultimate pursuit of excellence. Details reveal the true essence.

Efforts for Win-Win Cooperation

Since its listing in 2022, AOXMED has actively engaged in academic pursuits. As a council member of China Anti-aging Promoting Association, the company serves as the organizer of the Expert Consensus on the Application of Anti-Aging Skin Care Products for Facial Rejuvenation in China, as well as a diamond sponsor of the 6th Academic Annual Conference organized by the Skin Professional Committee of the Chinese Non-government Medical Institutions Association in 2022. So far, the brand has partnered with many hospitals and clinics to conduct clinical research and clinical observation.

According to the latest report, the luxury goods market in China is growing rapidly, ahead of the global average. As the high-end consumer market continues to expand, the purchasing power of Chinese consumers is on the rise. They seek quality products and services as self-investments, with a notably growing inclination towards medical beauty treatments.

Therefore, medical beauty institutions targeting young consumers must be more sensitive to evolving customer needs across various life stages. Moreover, these institutions should develop personalized, long-term skin management programs to retain customers and meet their advanced needs effectively, preventing customer loss. AOXMED is dedicated to working with institutions to optimize the management of our current customer base. We focus on increasing customer loyalty and, based on this foundation, we strive for upgrading consumer demands and facilitating cross-category connections, thereby enhancing customer value.

Comprehensive Analysis of Aging Targets based on Cosmeceutical Science

For specific causes of aging: ：
● Inhibition of inflammageing by suppressing pro-inflammatory cytokines and matrix metalloproteinases
● Antioxidant by reducing ROS production and protecting DNA
● Anti-collagen glycation by impeding the non-enzymatic condensation of reducing sugars with collagen amino groups
● Telomere repair by using the telomere protein pathway to delay telomere shortening and preserve replication activity with each cell division.

For specific parts of aging skin:
● Enhance the structure of the epidermal barrier by supplementing intercellular lipids (grout) and boosting the expression of keratinized envelope proteins (bricks)
● Promote and supplement the dermal extracellular matrix by synthesizing secretory collagen and glycosaminoglycan
● Relieve microexpressions by inhibiting the acetylcholine pathway and the transmission of sodium ion electronic signals

Skin Characteristics and Anti-aging Needs of Chinese

In comparison to white individuals, Chinese individuals typically have a thinner stratum corneum in their skin and slightly weaker anti-irritation ability. This often results in increased skin sensitivity and a higher likelihood of irritation when using certain products. In addition, the skin of Chinese people is intolerant to pain. According to the genetic analysis on sensitivity of Chinese people, in the TRPV1 (capsaicin receptor) gene, the frequency of risk alleles in the Chinese Han population is generally higher than that of white people in Europe and America. TRPV1 is best known for its function in nociceptive neurons, and one of the pathways that retinol causes irritation is to activate TRPV1. Therefore, the use of retinol skincare products is more likely to activate the TRPV1 mechanism, potentially leading to a tingling sensation on the skin. As a result, high-end skin care brands often use cell lysis filtrate and bio-polypeptides to offer customers a better experience.

Enhancing Premium Anti-Aging Ingredients through Cosmeceutical Science

Formula Analysis of MLYAAT-1002® Multidimensional Anti-aging Essence:
Cell lysis filtrate acting on the epidermal barrier: Filtrate from fermentation and lysis of rare cordyceps mycelial cells
● Promoting epidermal cell keratinization envelope (bricks) and fibroblast activity;
Peptide+ acting on the dermis: A patented combination of morin and polypeptide:
● A patented botulinum-like toxin 1+1 acting on mood wrinkles to reduce nerve impulses.
● Dual-channel inhibition of neuromuscular related cholinergic pathways and sodium ion pathways, with early onset and lasting effect;
Patented combinations including ergothioneine for cell activating:
● Antioxidant inflammation, protection of DNA telomeres, maintenance of cell proliferation limit.

As for the ingredient concentration dilution resulting from the blending of multiple essences, AOXMED screened over 200 anti-aging active substances through orthogonal experiments, tested over 5,000 formula combinations, and finally developed a multi-target patented combination. In view of the thin stratum corneum and rich capsaicin receptors of Chinese people, this ingredient excludes hydroxyl acid, ascorbic acid, and retinol, as they are easy to cause irritation. MLYAAT-1002® multi-dimensional anti-aging essence, the exclusive ingredient of AOXMED, serves as the foundation of almost all formulas of the brand's products.